Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PROCARDIS	ClinVar	3.51e-01	2.15e-01	2.21e-01	2.32e-04
ClinVar	PROCARDIS	2.65e-01	5.42e-01	3.91e-01	8.42e-01



Evaluating how well PROCARDIS genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS	ClinVar	0.66	-0.49	0.66	0.07	3.04
ClinVar	PROCARDIS	0.51	-0.27	-0.65	-0.14	0.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS	ClinVar	0.00	-0.57	-0.33	-0.35	0.73
ClinVar	PROCARDIS	0.00	-0.25	-0.66	-0.32	-0.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PROCARDIS	74	73	1-Mar
ClinVar	39	39