Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PROCARDIS-rare	ClinVar	6.71e-02	6.76e-02	1.58e-02	2.08e-07
ClinVar	PROCARDIS-rare	1.67e-02	4.54e-01	8.49e-03	1.91e-01



Evaluating how well PROCARDIS-rare genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS-rare	ClinVar	0.74	1.01	2.17	1.02	5.52
ClinVar	PROCARDIS-rare	0.54	0.85	0.67	0.70	1.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS-rare	ClinVar	0.00	0.21	1.51	0.30	4.26
ClinVar	PROCARDIS-rare	0.01	0.79	0.63	0.83	0.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PROCARDIS-rare	197	195	6-Mar;8-Mar
ClinVar	39	39