Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
01_3 Exclusive	GWAScat	1.23e-02	5.34e-01	1.67e-01	6.55e-04
GWAScat Exclusive	01_3	2.14e-01	8.25e-01	3.93e-01	7.05e-02
01_3 Exclusive	GWAScat Exclusive	9.42e-03	5.57e-01	2.69e-01	6.26e-04
GWAScat Exclusive	01_3 Exclusive	9.97e-02	8.76e-01	6.14e-01	8.20e-02
01_3 Exclusive	Overlap	6.80e-02	5.99e-02	5.99e-02	2.75e-01
GWAScat Exclusive	Overlap	5.01e-01	5.79e-01	5.40e-01	5.40e-01
Overlap	Exclusives	1.12e-01	3.03e-03	3.88e-40	3.56e-06



Evaluating how well 01_3 genes are linked to GWAScat genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_3 Exclusive	GWAScat	0.56	0.18	-0.20	0.29	2.57
GWAScat Exclusive	01_3	0.57	-0.53	0.54	0.25	2.10
01_3 Exclusive	GWAScat Exclusive	0.55	0.12	-0.67	-0.05	2.93
GWAScat Exclusive	01_3 Exclusive	0.57	-0.85	0.12	-0.11	2.06
01_3 Exclusive	Overlap	0.75	2.60	2.61	2.67	1.40
GWAScat Exclusive	Overlap	0.58	2.65	2.53	1.98	0.49
Overlap	Exclusives	0.59	0.89	3.93	0.82	5.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
01_3 Exclusive	GWAScat	0.01	-0.01	-0.97	0.19	0.98
GWAScat Exclusive	01_3	0.01	-0.24	1.06	0.12	2.17
01_3 Exclusive	GWAScat Exclusive	0.01	0.08	-1.20	-0.01	0.87
GWAScat Exclusive	01_3 Exclusive	0.00	-0.92	-0.30	-0.59	1.28
01_3 Exclusive	Overlap	0.00	0.96	4.37	1.19	0.10
GWAScat Exclusive	Overlap	0.01	569.62	2.89	60.17	23.91
Overlap	Exclusives	0.03	3.19	12.90	3.56	9.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
01_3 Exclusive	73	72	LOC554223
GWAScat Exclusive	230	226	CYP2D7;CORO7-PAM16;LSM 1.00;LINC02210-CRHR1
Overlap	2	2