Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
001_2 Exclusive	GWAScat	2.73e-01	2.09e-01	8.87e-02	4.07e-06
GWAScat Exclusive	001_2	5.96e-01	6.86e-01	1.20e-01	2.79e-01
001_2 Exclusive	GWAScat Exclusive	3.39e-01	2.43e-01	1.01e-01	1.43e-06
GWAScat Exclusive	001_2 Exclusive	3.02e-01	6.59e-01	1.73e-01	1.96e-01
001_2 Exclusive	Overlap	5.40e-01	1.54e-01	5.66e-01	6.20e-01
GWAScat Exclusive	Overlap	3.72e-01	5.40e-01	5.14e-01	5.40e-01
Overlap	Exclusives	5.58e-02	5.60e-04	8.43e-33	8.47e-07



Evaluating how well 001_2 genes are linked to GWAScat genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
001_2 Exclusive	GWAScat	0.60	1.42	2.42	1.77	5.02
GWAScat Exclusive	001_2	0.58	0.51	1.07	0.94	2.01
001_2 Exclusive	GWAScat Exclusive	0.60	1.32	2.44	1.84	5.78
GWAScat Exclusive	001_2 Exclusive	0.58	-0.34	0.60	0.57	1.80
001_2 Exclusive	Overlap	0.57	1.70	2.10	1.46	0.36
GWAScat Exclusive	Overlap	0.58	3.46	2.47	2.26	0.53
Overlap	Exclusives	0.60	0.87	5.26	0.95	6.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
001_2 Exclusive	GWAScat	0.01	0.94	0.75	1.32	2.58
GWAScat Exclusive	001_2	0.00	1.03	1.51	2.79	1.80
001_2 Exclusive	GWAScat Exclusive	0.01	0.67	0.72	1.13	3.86
GWAScat Exclusive	001_2 Exclusive	0.00	-0.39	-0.15	0.45	0.20
001_2 Exclusive	Overlap	0.00	1.93	8.94	0.40	0.70
GWAScat Exclusive	Overlap	0.01	220.78	368.07	102.08	54.47
Overlap	Exclusives	0.02	3.73	17.33	4.43	10.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
001_2 Exclusive	46	45	LOC554223
GWAScat Exclusive	230	226	LSM 1.00;CORO7-PAM16;LINC02210-CRHR1;CYP2D7
Overlap	2	2