Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
001_5Rare	GWAScat	8.93e-02	4.55e-01	2.04e-02	8.11e-03
GWAScat	001_5Rare	4.63e-02	9.65e-01	4.42e-01	5.37e-02



Evaluating how well 001_5Rare genes are linked to GWAScat genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
001_5Rare	GWAScat	0.55	-0.41	-0.93	0.02	2.84
GWAScat	001_5Rare	0.59	-1.76	-0.42	-0.70	2.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
001_5Rare	GWAScat	0.01	-0.71	-1.42	-0.30	0.96
GWAScat	001_5Rare	0.01	-1.69	-0.72	-0.82	1.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
001_5Rare	76	73	2244;https://string-db.org/cgi/network?taskId=b7YojFsXWxOz&sessionId=bBeoYSq9FV5C;2246
GWAScat	232	228	LINC02210-CRHR1;CORO7-PAM16;CYP2D7;LSM 1.00