Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF0001_AC5	1.01e-10	4.33e-01	2.84e-02	1.90e-01
AF0001_AC5	Viral	1.39e-01	9.05e-02	1.97e-04	1.08e-08



Evaluating how well Viral genes are linked to AF0001_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC5	0.55	-3.09	-1.50	-0.43	1.87
AF0001_AC5	Viral	0.67	-0.03	-0.31	0.76	6.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC5	0.01	-2.31	-0.89	-0.26	0.47
AF0001_AC5	Viral	0.01	-0.58	-2.16	-0.01	2.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	FCER;Mig;MBL3P;HLA;HLA-Cw;HLA-DRB4;SNORA31;HLA-DRB3;SRY;TNFα;IFNL4;IL12;UNC93B
AF0001_AC5	104	104