Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF0001_AC5	2.96e-09	4.65e-01	2.50e-02	9.54e-02
AF0001_AC5	Covid	2.21e-02	1.50e-01	5.22e-02	7.35e-08



Evaluating how well Covid genes are linked to AF0001_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC5	0.55	-2.47	-1.31	-0.50	1.97
AF0001_AC5	Covid	0.67	-0.50	-0.74	0.32	5.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC5	0.01	-2.09	-1.16	-0.29	1.18
AF0001_AC5	Covid	0.01	-0.76	-2.27	-0.27	4.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;SRY;MBL3P;HLA-DRB4
AF0001_AC5	104	104