Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF0001_AC4	1.73e-07	9.38e-01	1.06e-02	1.44e-02
AF0001_AC4	Viral	1.49e-01	3.49e-02	3.08e-06	3.63e-13



Evaluating how well Viral genes are linked to AF0001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC4	0.58	-1.45	-0.04	0.11	2.65
AF0001_AC4	Viral	0.70	0.63	1.51	1.04	8.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC4	0.01	-1.31	-0.14	0.13	2.06
AF0001_AC4	Viral	0.01	-0.35	-1.26	0.26	7.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	FCER;HLA-DRB3;IL12;TNFα;SRY;IFNL4;SNORA31;UNC93B;HLA-Cw;HLA-DRB4;Mig;MBL3P;HLA
AF0001_AC4	95	95