Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF0001_AC4	2.62e-06	7.86e-01	8.44e-03	1.52e-02
AF0001_AC4	Covid	2.24e-01	7.21e-02	1.16e-05	1.38e-11



Evaluating how well Covid genes are linked to AF0001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC4	0.58	-0.95	-0.16	0.41	2.68
AF0001_AC4	Covid	0.71	0.40	1.14	1.18	6.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC4	0.01	-1.34	-0.21	0.37	1.89
AF0001_AC4	Covid	0.01	-0.47	-1.00	0.42	3.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;UNC93B;MBL3P;SRY
AF0001_AC4	95	95