Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF0001_AC4	1.05e-04	4.16e-01	1.41e-01	2.16e-03
AF0001_AC4	Casanova	5.68e-02	2.88e-01	1.93e-02	1.74e-03



Evaluating how well Casanova genes are linked to AF0001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC4	0.59	0.98	0.16	0.28	3.23
AF0001_AC4	Casanova	0.76	-0.26	1.74	0.89	2.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC4	0.01	0.65	-0.27	0.45	1.11
AF0001_AC4	Casanova	0.00	-0.32	1.01	0.09	0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF0001_AC4	95	95