Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF0001_AC2	1.43e-06	7.64e-01	3.93e-02	6.21e-02
AF0001_AC2	Covid	4.49e-01	3.58e-01	1.88e-03	3.69e-09



Evaluating how well Covid genes are linked to AF0001_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC2	0.57	-1.46	-0.36	-0.18	2.21
AF0001_AC2	Covid	0.69	0.12	0.72	0.72	5.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC2	0.01	-1.38	-0.52	-0.20	1.18
AF0001_AC2	Covid	0.01	-0.67	-1.31	0.07	4.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;MBL3P;UNC93B;SRY
AF0001_AC2	88	88