Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF0001_AC2	1.47e-03	4.53e-01	1.16e-01	2.03e-03
AF0001_AC2	Casanova	1.60e-02	4.10e-01	1.49e-01	1.89e-02



Evaluating how well Casanova genes are linked to AF0001_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC2	0.60	1.19	0.47	0.52	3.19
AF0001_AC2	Casanova	0.68	-0.97	0.37	0.31	2.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC2	0.01	0.16	-0.50	0.50	1.56
AF0001_AC2	Casanova	0.00	-0.76	-0.27	-0.22	0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF0001_AC2	88	88