Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF001_AC5	4.82e-09	6.45e-01	8.80e-02	5.88e-03
AF001_AC5	Viral	7.70e-01	6.83e-01	7.14e-04	1.59e-08



Evaluating how well Viral genes are linked to AF001_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC5	0.56	-1.11	-0.13	0.39	2.17
AF001_AC5	Viral	0.68	0.72	0.45	0.90	6.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC5	0.01	-1.28	-0.29	0.22	1.20
AF001_AC5	Viral	0.01	-0.08	-1.05	0.14	2.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA;IL12;HLA-Cw;SRY;HLA-DRB3;FCER;MBL3P;TNFα;IFNL4;Mig;UNC93B;HLA-DRB4;SNORA31
AF001_AC5	112	109	LOC101928841;PPIAL4E;CCDC7