Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF001_AC4	9.27e-07	4.11e-01	7.66e-02	3.67e-03
AF001_AC4	Viral	2.15e-01	3.11e-01	1.55e-04	6.63e-11



Evaluating how well Viral genes are linked to AF001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC4	0.57	0.22	0.90	1.03	2.97
AF001_AC4	Viral	0.70	1.10	1.92	0.98	7.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC4	0.01	-1.22	0.67	0.69	0.76
AF001_AC4	Viral	0.01	0.32	0.47	0.42	7.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	UNC93B;Mig;IFNL4;MBL3P;HLA;IL12;TNFα;FCER;SNORA31;HLA-DRB3;HLA-Cw;HLA-DRB4;SRY
AF001_AC4	106	103	CCDC7;LOC101928841;PPIAL4E