Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF001_AC4	1.02e-06	9.88e-01	1.28e-01	8.39e-02
AF001_AC4	Covid	2.89e-01	4.64e-01	7.65e-04	1.89e-08



Evaluating how well Covid genes are linked to AF001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC4	0.56	-0.54	-0.22	0.31	2.00
AF001_AC4	Covid	0.70	0.82	1.12	0.97	7.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC4	0.01	-1.28	0.11	0.48	1.53
AF001_AC4	Covid	0.01	0.03	0.04	0.43	2.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;MBL3P;HLA-DRB4;SRY
AF001_AC4	106	103	CCDC7;PPIAL4E;LOC101928841