Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF001_AC4	1.14e-05	8.00e-01	3.31e-01	4.57e-02
AF001_AC4	Casanova	7.38e-01	8.50e-02	1.46e-02	4.11e-04



Evaluating how well Casanova genes are linked to AF001_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC4	0.55	-0.07	-0.55	-0.30	1.84
AF001_AC4	Casanova	0.81	0.58	2.48	1.26	3.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC4	0.01	0.37	-0.14	0.10	0.72
AF001_AC4	Casanova	0.00	-0.14	1.03	0.34	0.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF001_AC4	106	103	CCDC7;LOC101928841;PPIAL4E