Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF001_AC2	8.42e-07	5.27e-01	1.66e-01	2.34e-02
AF001_AC2	Viral	3.11e-01	5.95e-01	3.13e-03	9.95e-10



Evaluating how well Viral genes are linked to AF001_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC2	0.55	-0.13	0.28	0.59	2.00
AF001_AC2	Viral	0.70	0.91	1.62	0.94	6.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF001_AC2	0.01	-0.42	0.27	0.57	0.55
AF001_AC2	Viral	0.01	0.11	0.05	0.37	6.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA;HLA-DRB3;UNC93B;SRY;SNORA31;MBL3P;IFNL4;HLA-Cw;IL12;HLA-DRB4;TNFα;Mig;FCER
AF001_AC2	101	98	PPIAL4E;LOC101928841;CCDC7