Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF001_AC2	2.68e-08	8.78e-01	1.46e-01	2.44e-01
AF001_AC2	Covid	3.96e-01	7.71e-01	1.37e-02	3.86e-08



Evaluating how well Covid genes are linked to AF001_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC2	0.54	-1.16	-0.45	-0.15	1.30
AF001_AC2	Covid	0.69	0.79	1.06	0.66	6.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC2	0.01	-0.60	-0.10	0.24	0.30
AF001_AC2	Covid	0.01	0.14	-0.05	0.10	5.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	SRY;UNC93B;MBL3P;HLA-DRB4
AF001_AC2	101	98	LOC101928841;CCDC7;PPIAL4E