Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF001_AC2	3.87e-05	8.75e-01	5.32e-01	1.02e-01
AF001_AC2	Casanova	6.83e-01	2.78e-01	1.31e-01	9.78e-04



Evaluating how well Casanova genes are linked to AF001_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC2	0.54	-0.01	-0.60	-0.20	1.52
AF001_AC2	Casanova	0.79	0.64	2.59	0.76	3.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC2	0.01	0.40	-0.26	0.19	0.79
AF001_AC2	Casanova	0.00	0.07	2.38	-0.08	1.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF001_AC2	101	98	CCDC7;PPIAL4E;LOC101928841