Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF01_AC5	2.99e-06	7.59e-01	4.08e-03	7.83e-02
AF01_AC5	Viral	1.16e-01	4.43e-02	3.11e-03	7.37e-11



Evaluating how well Viral genes are linked to AF01_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC5	0.55	1.00	0.49	0.71	2.25
AF01_AC5	Viral	0.70	0.74	2.64	1.01	7.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC5	0.01	1.21	0.69	1.03	0.66
AF01_AC5	Viral	0.01	0.46	3.72	1.12	11.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	FCER;HLA;HLA-DRB3;SNORA31;IFNL4;UNC93B;TNFα;HLA-DRB4;SRY;Mig;MBL3P;IL12;HLA-Cw
AF01_AC5	112	110	C1GALT1C1L;CCDC7