Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF01_AC5	3.50e-06	8.87e-01	8.70e-01	3.70e-01
AF01_AC5	Casanova	6.73e-01	7.58e-01	7.62e-01	1.82e-01



Evaluating how well Casanova genes are linked to AF01_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC5	0.53	0.68	-0.40	-0.11	1.44
AF01_AC5	Casanova	0.62	-0.44	-0.79	-0.48	1.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC5	0.01	0.32	-0.30	-0.24	0.27
AF01_AC5	Casanova	0.00	-0.44	-0.83	-0.55	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF01_AC5	112	110	C1GALT1C1L;CCDC7