Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF01_AC4	1.36e-04	6.73e-01	3.20e-03	6.10e-02
AF01_AC4	Viral	1.26e-01	1.14e-01	1.25e-03	8.65e-11



Evaluating how well Viral genes are linked to AF01_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC4	0.55	2.12	0.62	1.15	2.07
AF01_AC4	Viral	0.71	0.90	2.66	1.53	7.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC4	0.01	0.81	0.98	0.24	1.06
AF01_AC4	Viral	0.01	0.94	6.09	2.00	6.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA-DRB3;Mig;HLA;HLA-DRB4;TNFα;SNORA31;MBL3P;FCER;SRY;UNC93B;HLA-Cw;IL12;IFNL4
AF01_AC4	107	105	C1GALT1C1L;CCDC7