Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF01_AC4	6.28e-05	6.32e-01	1.54e-02	4.14e-01
AF01_AC4	Covid	4.09e-01	5.41e-01	1.87e-01	1.27e-07



Evaluating how well Covid genes are linked to AF01_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF01_AC4	0.54	0.99	0.20	0.77	1.63
AF01_AC4	Covid	0.69	0.46	1.41	0.55	6.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF01_AC4	0.01	0.08	1.03	1.23	1.78
AF01_AC4	Covid	0.01	0.67	3.30	0.60	8.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	MBL3P;SRY;UNC93B;HLA-DRB4
AF01_AC4	107	105	CCDC7;C1GALT1C1L