Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF01_AC4	1.84e-04	9.82e-01	6.36e-01	3.82e-01
AF01_AC4	Casanova	9.35e-01	7.48e-01	9.35e-01	1.14e-01



Evaluating how well Casanova genes are linked to AF01_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC4	0.54	1.34	-0.10	0.02	1.26
AF01_AC4	Casanova	0.67	-0.11	-0.25	0.11	2.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC4	0.01	1.27	0.00	0.07	0.77
AF01_AC4	Casanova	0.00	-0.48	-0.47	-0.31	0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF01_AC4	107	105	C1GALT1C1L;CCDC7