Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF01_AC2	1.11e-03	4.85e-01	6.28e-03	9.72e-02
AF01_AC2	Viral	1.05e-01	4.99e-02	4.64e-02	5.57e-11



Evaluating how well Viral genes are linked to AF01_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC2	0.54	1.79	0.88	1.04	1.47
AF01_AC2	Viral	0.71	1.02	3.03	1.04	7.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC2	0.01	1.95	1.47	0.17	1.50
AF01_AC2	Viral	0.01	1.31	6.60	1.31	11.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	IL12;MBL3P;SNORA31;IFNL4;UNC93B;FCER;HLA-DRB3;HLA-Cw;SRY;TNFα;HLA-DRB4;HLA;Mig
AF01_AC2	99	97	C1GALT1C1L;CCDC7