Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF01_AC2	2.11e-03	8.39e-01	4.10e-01	5.18e-01
AF01_AC2	Casanova	5.09e-01	6.78e-01	6.12e-01	1.17e-01



Evaluating how well Casanova genes are linked to AF01_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC2	0.54	1.73	0.41	0.16	1.13
AF01_AC2	Casanova	0.63	-0.34	-0.61	-0.42	1.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC2	0.01	1.04	0.29	-0.14	0.57
AF01_AC2	Casanova	0.00	-0.50	-0.51	-0.48	0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF01_AC2	99	97	CCDC7;C1GALT1C1L