Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF1_AC5	4.19e-06	6.43e-01	5.33e-02	8.87e-01
AF1_AC5 Exclusive	Viral	8.23e-01	6.09e-01	8.93e-01	1.21e-06
Viral Exclusive	AF1_AC5 Exclusive	4.37e-06	6.74e-01	9.62e-02	9.09e-01
AF1_AC5 Exclusive	Viral Exclusive	9.68e-01	7.26e-01	8.79e-01	6.64e-07
Viral Exclusive	Overlap	1.12e-01	2.92e-01	9.92e-02	2.06e-01
AF1_AC5 Exclusive	Overlap	2.65e-01	4.17e-01	3.35e-01	2.65e-01
Overlap	Exclusives	8.70e-03	3.41e-05	1.41e-05	8.08e-11



Evaluating how well Viral genes are linked to AF1_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF1_AC5	0.51	-0.76	-0.84	-0.11	0.25
AF1_AC5 Exclusive	Viral	0.65	-0.01	-0.00	0.24	5.53
Viral Exclusive	AF1_AC5 Exclusive	0.51	-1.03	-0.83	-0.14	0.22
AF1_AC5 Exclusive	Viral Exclusive	0.65	0.12	0.10	0.26	6.15
Viral Exclusive	Overlap	0.87	2.37	1.23	1.60	1.26
AF1_AC5 Exclusive	Overlap	0.19	-1.08	-0.83	-0.96	-1.08
Overlap	Exclusives	0.63	0.74	3.88	1.00	6.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF1_AC5	0.00	-0.68	-0.48	-0.26	-0.03
AF1_AC5 Exclusive	Viral	0.01	-0.39	-0.94	-0.21	2.23
Viral Exclusive	AF1_AC5 Exclusive	0.00	-0.79	-0.28	-0.31	0.05
AF1_AC5 Exclusive	Viral Exclusive	0.01	-0.34	-0.90	-0.17	3.64
Viral Exclusive	Overlap	0.00	2.92	-0.18	1.74	0.43
AF1_AC5 Exclusive	Overlap	0.00	-0.31	-0.39	-0.33	-0.23
Overlap	Exclusives	0.01	-0.14	3.26	0.18	6.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-Cw;Mig;UNC93B;SNORA31;MBL3P;FCER;HLA-DRB3;HLA-DRB4;HLA;SRY;TNFα;IFNL4;IL12
AF1_AC5 Exclusive	80	80	
Overlap	1	1