Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	AF1_AC5	1.48e-04	4.21e-01	1.56e-01	7.80e-01
AF1_AC5 Exclusive	Covid	4.83e-01	5.69e-01	9.30e-01	5.78e-06
Covid Exclusive	AF1_AC5 Exclusive	1.30e-04	3.62e-01	1.75e-01	8.92e-01
AF1_AC5 Exclusive	Covid Exclusive	8.49e-01	4.70e-01	8.59e-01	1.50e-05
Covid Exclusive	Overlap	1.33e-01	2.52e-01	1.41e-01	1.66e-01
AF1_AC5 Exclusive	Overlap	2.52e-01	4.91e-01	3.51e-01	3.06e-01
Overlap	Exclusives	2.51e-03	6.07e-05	5.89e-04	4.23e-10



Evaluating how well Covid genes are linked to AF1_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF1_AC5	0.51	-0.82	-0.60	-0.10	0.28
AF1_AC5 Exclusive	Covid	0.65	-0.20	-0.46	0.00	4.64
Covid Exclusive	AF1_AC5 Exclusive	0.50	-1.14	-0.76	-0.08	0.12
AF1_AC5 Exclusive	Covid Exclusive	0.65	0.07	-0.34	0.10	4.77
Covid Exclusive	Overlap	0.87	2.15	1.36	1.63	1.40
AF1_AC5 Exclusive	Overlap	0.19	-1.23	-0.89	-1.06	-1.07
Overlap	Exclusives	0.63	0.69	4.19	0.97	5.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF1_AC5	0.00	-0.74	-0.33	-0.26	-0.05
AF1_AC5 Exclusive	Covid	0.01	-0.52	-1.24	-0.38	1.06
Covid Exclusive	AF1_AC5 Exclusive	0.00	-0.83	-0.36	-0.25	-0.15
AF1_AC5 Exclusive	Covid Exclusive	0.01	-0.36	-1.14	-0.33	3.18
Covid Exclusive	Overlap	0.00	0.63	-0.10	0.11	0.03
AF1_AC5 Exclusive	Overlap	0.00	-0.39	-0.50	-0.25	-0.31
Overlap	Exclusives	0.01	-0.25	2.91	0.06	3.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	UNC93B;MBL3P;SRY;HLA-DRB4
AF1_AC5 Exclusive	80	80	
Overlap	1	1