Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF1_AC4	1.63e-03	6.37e-01	3.56e-02	4.89e-01
AF1_AC4	Viral	2.06e-01	5.14e-01	4.72e-02	3.16e-08



Evaluating how well Viral genes are linked to AF1_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF1_AC4	0.52	0.46	-0.01	0.34	0.66
AF1_AC4	Viral	0.67	0.51	0.88	0.60	6.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF1_AC4	0.00	-0.34	0.14	-0.09	0.49
AF1_AC4	Viral	0.01	0.02	0.21	0.24	5.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA;IL12;IFNL4;SNORA31;Mig;HLA-DRB3;HLA-Cw;MBL3P;TNFα;SRY;HLA-DRB4;FCER;UNC93B
AF1_AC4	77	77