Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF1_AC4	8.53e-03	2.70e-01	8.38e-02	4.52e-01
AF1_AC4	Covid	1.39e-01	5.34e-01	4.79e-02	6.68e-07



Evaluating how well Covid genes are linked to AF1_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF1_AC4	0.52	0.22	-0.24	0.23	0.65
AF1_AC4	Covid	0.67	0.49	0.77	0.54	5.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF1_AC4	0.00	-0.61	-0.07	-0.15	0.53
AF1_AC4	Covid	0.01	-0.11	-0.07	0.10	4.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;HLA-DRB4;SRY;MBL3P
AF1_AC4	77	77