Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF1_AC4	1.43e-04	3.11e-01	6.90e-01	9.05e-01
AF1_AC4	Casanova	5.38e-01	3.97e-01	5.09e-01	1.69e-02



Evaluating how well Casanova genes are linked to AF1_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF1_AC4	0.49	-1.01	-1.48	-0.90	-0.41
AF1_AC4	Casanova	0.69	0.25	0.07	0.15	2.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF1_AC4	0.00	-0.66	-0.62	-0.52	-0.25
AF1_AC4	Casanova	0.00	-0.32	-0.60	-0.37	0.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF1_AC4	77	77