Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF1_AC2	2.41e-03	4.46e-01	4.74e-02	5.74e-01
AF1_AC2	Viral	4.58e-01	3.58e-01	3.58e-01	6.47e-08



Evaluating how well Viral genes are linked to AF1_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF1_AC2	0.50	0.16	-0.26	0.04	0.06
AF1_AC2	Viral	0.67	0.50	1.29	0.57	6.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF1_AC2	0.00	0.32	0.10	-0.12	-0.01
AF1_AC2	Viral	0.01	0.02	0.76	0.12	2.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	TNFα;SRY;IL12;MBL3P;Mig;HLA-DRB4;HLA-DRB3;HLA-Cw;HLA;IFNL4;SNORA31;FCER;UNC93B
AF1_AC2	70	70