Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF1_AC2	5.59e-03	1.97e-01	5.66e-02	2.87e-01
AF1_AC2	Covid	4.36e-01	3.05e-01	5.65e-01	1.25e-07



Evaluating how well Covid genes are linked to AF1_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF1_AC2	0.50	-0.00	-0.28	-0.12	0.11
AF1_AC2	Covid	0.67	0.47	1.13	0.44	5.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF1_AC2	0.00	-0.12	-0.05	-0.05	0.38
AF1_AC2	Covid	0.01	-0.03	0.32	-0.05	1.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;MBL3P;HLA-DRB4;SRY
AF1_AC2	70	70