Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF1_AC2	2.24e-04	4.04e-01	8.12e-01	7.69e-01
AF1_AC2	Casanova	5.04e-01	1.37e-01	8.76e-02	3.34e-02



Evaluating how well Casanova genes are linked to AF1_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF1_AC2	0.47	-1.08	-1.69	-0.96	-0.96
AF1_AC2	Casanova	0.62	-0.02	-0.77	-0.47	1.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF1_AC2	0.00	-0.79	-0.88	-0.35	-0.40
AF1_AC2	Casanova	0.00	-0.41	-0.92	-0.41	0.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF1_AC2	70	70