Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Combo	1.78e-01	6.07e-01	2.32e-02	8.58e-03
Combo	Viral	1.46e-06	1.88e-06	1.18e-15	7.60e-19



Evaluating how well Viral genes are linked to Combo genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Combo	0.65	1.97	1.50	2.01	2.90
Combo	Viral	0.78	1.97	7.61	2.56	11.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Combo	0.00	-0.12	2.06	0.21	2.00
Combo	Viral	0.02	1.74	9.75	3.99	19.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	UNC93B;MBL3P;Mig;HLA-DRB3;FCER;SNORA31;TNFα;IFNL4;HLA;IL12;HLA-Cw;HLA-DRB4;SRY
Combo	35	35