Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
rare_001_4 Exclusive	ClinvarGold	3.26e-01	9.53e-01	1.14e-01	3.31e-02
ClinvarGold Exclusive	rare_001_4	9.99e-01	7.49e-01	7.38e-03	5.39e-03
rare_001_4 Exclusive	ClinvarGold Exclusive	1.77e-01	9.67e-01	1.69e-01	3.57e-02
ClinvarGold Exclusive	rare_001_4 Exclusive	9.42e-01	8.53e-01	1.25e-02	4.61e-03
rare_001_4 Exclusive	Overlap	1.05e-01	3.20e-01	1.05e-01	9.92e-02
ClinvarGold Exclusive	Overlap	9.92e-02	9.92e-02	1.12e-01	1.05e-01
Overlap	Exclusives	3.48e-05	6.10e-05	2.53e-17	4.09e-09



Evaluating how well rare_001_4 genes are linked to ClinvarGold genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare_001_4 Exclusive	ClinvarGold	0.65	0.40	0.16	0.18	2.61
ClinvarGold Exclusive	rare_001_4	0.61	0.02	0.95	0.10	2.95
rare_001_4 Exclusive	ClinvarGold Exclusive	0.63	-0.14	-0.15	0.23	2.36
ClinvarGold Exclusive	rare_001_4 Exclusive	0.60	-0.05	0.88	-0.08	3.04
rare_001_4 Exclusive	Overlap	0.95	1.26	1.13	1.25	2.05
ClinvarGold Exclusive	Overlap	0.98	1.83	2.00	1.75	1.55
Overlap	Exclusives	0.71	2.60	5.32	3.33	7.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare_001_4 Exclusive	ClinvarGold	0.00	0.31	-0.25	0.01	1.03
ClinvarGold Exclusive	rare_001_4	0.00	-0.36	0.20	0.05	1.64
rare_001_4 Exclusive	ClinvarGold Exclusive	0.00	-0.49	-0.52	0.01	0.30
ClinvarGold Exclusive	rare_001_4 Exclusive	0.00	-0.45	-0.02	-0.30	0.42
rare_001_4 Exclusive	Overlap	0.00	0.88	0.67	0.41	8.05
ClinvarGold Exclusive	Overlap	0.00	10.71	27.54	3.12	5.98
Overlap	Exclusives	0.01	2.66	7.24	4.84	8.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
rare_001_4 Exclusive	68	68	
ClinvarGold Exclusive	27	25	SHANK3;PRODH
Overlap	1	1