Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GroupA	GroupB	6.69e-01	4.65e-01	8.97e-01	2.70e-02
GroupB	GroupA	9.01e-01	7.36e-01	7.60e-02	9.92e-01



Evaluating how well GroupA genes are linked to GroupB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.83	0.00	1.10	0.21	2.05
GroupB	GroupA	0.50	-0.06	-0.39	-0.28	0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.00	0.00	0.75	0.19	-0.09
GroupB	GroupA	0.00	0.12	-0.21	-0.20	-0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GroupA	5	5	
GroupB	4	4