Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SYNGENConsensus159 Exclusive	NEJM2021GS34	5.20e-12	2.05e-13	2.81e-16	3.86e-19
NEJM2021GS34 Exclusive	SYNGENConsensus159	2.35e-03	7.47e-03	8.92e-10	7.24e-07
SYNGENConsensus159 Exclusive	NEJM2021GS34 Exclusive	4.30e-07	5.25e-08	1.31e-09	8.69e-12
NEJM2021GS34 Exclusive	SYNGENConsensus159 Exclusive	1.47e-02	2.17e-02	6.99e-08	3.98e-05
SYNGENConsensus159 Exclusive	Overlap	2.05e-05	2.47e-05	2.58e-07	7.62e-09
NEJM2021GS34 Exclusive	Overlap	6.81e-10	1.05e-09	6.81e-10	8.47e-10
Overlap	Exclusives	2.74e-05	1.32e-03	1.87e-13	6.98e-07



Evaluating how well SYNGENConsensus159 genes are linked to NEJM2021GS34 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SYNGENConsensus159 Exclusive	NEJM2021GS34	0.95	2.97	8.22	3.04	9.26
NEJM2021GS34 Exclusive	SYNGENConsensus159	0.63	3.12	3.43	2.65	5.16
SYNGENConsensus159 Exclusive	NEJM2021GS34 Exclusive	0.94	2.78	6.90	3.09	7.08
NEJM2021GS34 Exclusive	SYNGENConsensus159 Exclusive	0.61	3.21	2.52	2.32	4.15
SYNGENConsensus159 Exclusive	Overlap	0.98	2.04	4.50	2.55	4.40
NEJM2021GS34 Exclusive	Overlap	1.00	2.52	5.72	2.52	5.52
Overlap	Exclusives	0.64	1.54	2.93	2.34	5.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SYNGENConsensus159 Exclusive	NEJM2021GS34	0.03	2.15	37.71	10.14	41.39
NEJM2021GS34 Exclusive	SYNGENConsensus159	0.05	34.20	49.05	29.24	63.51
SYNGENConsensus159 Exclusive	NEJM2021GS34 Exclusive	0.02	2.93	19.30	7.67	40.22
NEJM2021GS34 Exclusive	SYNGENConsensus159 Exclusive	0.01	8.07	5.48	4.10	7.49
SYNGENConsensus159 Exclusive	Overlap	0.02	0.79	21.19	9.76	12.22
NEJM2021GS34 Exclusive	Overlap	0.43	147.09	233.48	457.23	1311.00
Overlap	Exclusives	0.04	16.82	27.24	23.83	22.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SYNGENConsensus159 Exclusive	147	142	;DKK1.00;SSPO;C4B_2;BOP1.00
NEJM2021GS34 Exclusive	24	22	BABM2;CHECK2
Overlap	10	10