Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	BRCA-all-q01	2.50e-15	1.05e-04	4.34e-20	5.82e-21
BRCA-all-q01 Exclusive	Viral	6.08e-05	2.03e-06	3.72e-40	2.08e-28
Viral Exclusive	BRCA-all-q01 Exclusive	6.88e-16	7.86e-03	2.89e-15	1.21e-17
BRCA-all-q01 Exclusive	Viral Exclusive	1.32e-04	4.56e-06	2.67e-37	1.93e-23
Viral Exclusive	Overlap	8.74e-11	9.50e-09	8.74e-11	6.17e-10
BRCA-all-q01 Exclusive	Overlap	4.61e-03	4.64e-02	2.21e-08	1.18e-06
Overlap	Exclusives	8.83e-28	8.99e-23	2.04e-48	6.51e-53



Evaluating how well Viral genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-all-q01	0.72	-3.27	2.25	2.51	12.94
BRCA-all-q01 Exclusive	Viral	0.82	2.16	6.70	3.54	11.86
Viral Exclusive	BRCA-all-q01 Exclusive	0.71	-3.31	2.04	1.89	11.87
BRCA-all-q01 Exclusive	Viral Exclusive	0.81	2.14	7.28	3.59	9.75
Viral Exclusive	Overlap	0.99	2.70	5.90	3.27	4.81
BRCA-all-q01 Exclusive	Overlap	0.94	2.69	2.87	2.36	4.72
Overlap	Exclusives	0.79	3.34	12.08	3.96	21.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-all-q01	0.04	0.23	10.64	8.44	38.36
BRCA-all-q01 Exclusive	Viral	0.03	1.47	5.69	5.32	22.23
Viral Exclusive	BRCA-all-q01 Exclusive	0.03	-1.68	4.33	3.66	19.45
BRCA-all-q01 Exclusive	Viral Exclusive	0.02	1.61	6.67	6.08	23.57
Viral Exclusive	Overlap	0.16	49.12	251.71	151.45	69.19
BRCA-all-q01 Exclusive	Overlap	0.01	0.85	0.17	4.48	19.64
Overlap	Exclusives	0.10	10.52	51.14	22.50	105.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	113	100	HLA;SRY;HLA-Cw;HLA-DRB3;IFNL4;SNORA31;FCER;HLA-DRB4;IL12;TNFα;MBL3P;Mig;UNC93B
BRCA-all-q01 Exclusive	234	231	SOS 1;2021-03-07 00:00:00;DKK 1.00
Overlap	11	11