Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	BRCA-rare-q01	1.36e-14	6.81e-04	1.30e-20	3.30e-33
BRCA-rare-q01 Exclusive	Viral	5.65e-04	1.70e-05	6.74e-43	1.24e-25
Viral Exclusive	BRCA-rare-q01 Exclusive	4.45e-15	5.22e-03	9.97e-18	4.64e-32
BRCA-rare-q01 Exclusive	Viral Exclusive	1.14e-03	5.96e-05	6.21e-39	1.57e-23
Viral Exclusive	Overlap	2.62e-06	1.64e-04	2.62e-06	5.34e-06
BRCA-rare-q01 Exclusive	Overlap	1.70e-01	4.08e-01	1.16e-05	3.20e-04
Overlap	Exclusives	1.34e-19	3.34e-19	1.68e-51	1.42e-68



Evaluating how well Viral genes are linked to BRCA-rare-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-rare-q01	0.76	-4.05	3.96	2.36	13.34
BRCA-rare-q01 Exclusive	Viral	0.81	2.67	6.17	3.05	11.01
Viral Exclusive	BRCA-rare-q01 Exclusive	0.75	-4.32	3.03	1.72	12.10
BRCA-rare-q01 Exclusive	Viral Exclusive	0.80	2.69	5.41	2.81	11.17
Viral Exclusive	Overlap	0.99	2.26	3.93	2.42	4.52
BRCA-rare-q01 Exclusive	Overlap	0.93	0.94	1.40	1.42	3.48
Overlap	Exclusives	0.82	3.35	11.44	2.96	20.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-rare-q01	0.04	-2.21	8.61	5.28	29.41
BRCA-rare-q01 Exclusive	Viral	0.02	2.33	4.78	4.87	31.65
Viral Exclusive	BRCA-rare-q01 Exclusive	0.03	-2.82	4.59	2.22	15.51
BRCA-rare-q01 Exclusive	Viral Exclusive	0.02	2.49	4.58	3.57	14.15
Viral Exclusive	Overlap	0.09	47.46	68.73	139.71	79.77
BRCA-rare-q01 Exclusive	Overlap	0.00	1.06	-0.10	1.44	6.08
Overlap	Exclusives	0.09	7.64	47.22	13.27	82.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	118	105	MBL3P;Mig;HLA;TNFα;IL12;FCER;UNC93B;SNORA31;SRY;IFNL4;HLA-Cw;HLA-DRB3;HLA-DRB4
BRCA-rare-q01 Exclusive	216	215	CHD2
Overlap	6	6