Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	BRCA-rare-q001	2.53e-10	2.32e-01	1.42e-10	7.54e-18
BRCA-rare-q001 Exclusive	Viral	2.16e-01	3.27e-02	2.56e-24	2.61e-17
Viral Exclusive	BRCA-rare-q001 Exclusive	8.39e-11	6.57e-01	2.78e-08	1.94e-15
BRCA-rare-q001 Exclusive	Viral Exclusive	3.28e-01	3.98e-02	2.03e-22	3.90e-16
Viral Exclusive	Overlap	2.10e-05	1.30e-03	2.10e-05	4.13e-05
BRCA-rare-q001 Exclusive	Overlap	4.76e-01	3.07e-01	1.62e-03	6.18e-03
Overlap	Exclusives	5.90e-21	9.33e-20	1.38e-43	3.40e-49



Evaluating how well Viral genes are linked to BRCA-rare-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-rare-q001	0.75	-4.33	1.76	1.37	9.42
BRCA-rare-q001 Exclusive	Viral	0.75	-0.20	2.40	1.66	8.85
Viral Exclusive	BRCA-rare-q001 Exclusive	0.74	-5.88	0.89	1.00	8.62
BRCA-rare-q001 Exclusive	Viral Exclusive	0.74	-0.09	2.82	1.80	9.11
Viral Exclusive	Overlap	0.99	2.18	4.35	2.50	4.00
BRCA-rare-q001 Exclusive	Overlap	0.90	-0.49	0.77	1.62	2.94
Overlap	Exclusives	0.83	2.78	11.43	2.56	17.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	BRCA-rare-q001	0.02	-1.92	3.20	3.28	20.50
BRCA-rare-q001 Exclusive	Viral	0.02	-0.71	-0.15	2.09	6.27
Viral Exclusive	BRCA-rare-q001 Exclusive	0.01	-2.53	0.34	0.84	7.26
BRCA-rare-q001 Exclusive	Viral Exclusive	0.01	-0.66	-0.22	1.58	10.80
Viral Exclusive	Overlap	0.07	34.46	41.20	138.81	63.11
BRCA-rare-q001 Exclusive	Overlap	0.00	-0.60	-0.76	2.35	1.29
Overlap	Exclusives	0.09	7.94	50.12	15.57	103.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	119	106	SRY;MBL3P;IFNL4;HLA-Cw;HLA-DRB3;HLA;TNFα;HLA-DRB4;FCER;SNORA31;IL12;Mig;UNC93B
BRCA-rare-q001 Exclusive	114	114	
Overlap	5	5