Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	BRCA-all-q01	1.96e-13	1.19e-04	9.39e-22	5.41e-22
BRCA-all-q01 Exclusive	Covid	9.49e-07	1.68e-07	1.89e-36	1.29e-27
Covid Exclusive	BRCA-all-q01 Exclusive	5.75e-15	3.91e-03	2.80e-18	2.25e-19
BRCA-all-q01 Exclusive	Covid Exclusive	1.02e-05	4.81e-07	3.21e-33	4.72e-24
Covid Exclusive	Overlap	4.18e-08	7.39e-08	4.18e-08	9.59e-08
BRCA-all-q01 Exclusive	Overlap	1.95e-03	2.63e-02	2.85e-06	5.41e-05
Overlap	Exclusives	9.02e-20	7.27e-17	1.26e-38	4.87e-51



Evaluating how well Covid genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-all-q01	0.72	-2.54	2.51	2.44	12.55
BRCA-all-q01 Exclusive	Covid	0.86	2.55	7.47	3.32	11.01
Covid Exclusive	BRCA-all-q01 Exclusive	0.71	-3.14	1.94	2.26	11.41
BRCA-all-q01 Exclusive	Covid Exclusive	0.85	2.65	7.29	3.32	10.20
Covid Exclusive	Overlap	0.99	3.07	4.69	3.48	4.46
BRCA-all-q01 Exclusive	Overlap	0.93	3.15	3.04	2.14	4.38
Overlap	Exclusives	0.79	3.63	10.14	3.09	21.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-all-q01	0.04	0.14	8.62	8.05	25.64
BRCA-all-q01 Exclusive	Covid	0.03	2.25	9.65	6.16	36.14
Covid Exclusive	BRCA-all-q01 Exclusive	0.03	-1.09	5.10	4.88	20.59
BRCA-all-q01 Exclusive	Covid Exclusive	0.02	2.61	11.71	4.48	30.46
Covid Exclusive	Overlap	0.06	43.55	199.19	135.89	5.04
BRCA-all-q01 Exclusive	Overlap	0.00	4.14	1.14	3.09	4.61
Overlap	Exclusives	0.08	14.55	42.59	15.25	86.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	78	74	HLA-DRB4;MBL3P;UNC93B;SRY
BRCA-all-q01 Exclusive	237	234	SOS 1;2021-03-07 00:00:00;DKK 1.00
Overlap	8	8