Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	BRCA-all-q001	3.93e-09	5.09e-03	4.78e-13	1.51e-15
BRCA-all-q001 Exclusive	Covid	3.38e-06	6.04e-06	1.52e-29	2.01e-23
Covid Exclusive	BRCA-all-q001 Exclusive	5.73e-10	5.14e-02	5.81e-11	9.20e-15
BRCA-all-q001 Exclusive	Covid Exclusive	4.29e-05	4.05e-06	9.58e-30	9.92e-23
Covid Exclusive	Overlap	2.10e-05	3.15e-05	2.10e-05	2.63e-05
BRCA-all-q001 Exclusive	Overlap	7.42e-02	3.99e-01	1.35e-03	4.01e-03
Overlap	Exclusives	5.16e-18	4.55e-16	9.51e-35	1.21e-40



Evaluating how well Covid genes are linked to BRCA-all-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-all-q001	0.72	-2.52	2.04	2.23	10.20
BRCA-all-q001 Exclusive	Covid	0.84	2.08	7.43	3.71	10.48
Covid Exclusive	BRCA-all-q001 Exclusive	0.71	-3.58	1.36	1.98	9.88
BRCA-all-q001 Exclusive	Covid Exclusive	0.84	2.20	8.08	3.42	9.83
Covid Exclusive	Overlap	0.99	2.25	3.91	2.81	3.73
BRCA-all-q001 Exclusive	Overlap	0.88	0.81	1.65	1.52	2.78
Overlap	Exclusives	0.79	2.32	8.01	2.43	14.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-all-q001	0.03	-0.35	8.20	6.91	26.72
BRCA-all-q001 Exclusive	Covid	0.02	1.38	8.20	5.61	32.54
Covid Exclusive	BRCA-all-q001 Exclusive	0.02	-1.43	3.23	4.36	17.40
BRCA-all-q001 Exclusive	Covid Exclusive	0.02	1.08	9.53	5.24	11.27
Covid Exclusive	Overlap	0.08	49.76	224.72	98.69	490.88
BRCA-all-q001 Exclusive	Overlap	0.00	1.12	-0.29	2.94	10.30
Overlap	Exclusives	0.07	13.00	41.93	12.68	64.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	81	77	SRY;UNC93B;HLA-DRB4;MBL3P
BRCA-all-q001 Exclusive	148	147	2021-03-07 00:00:00
Overlap	5	5