Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	BRCA-rare-q001	9.26e-08	1.02e-01	4.80e-11	1.78e-16
BRCA-rare-q001 Exclusive	Covid	8.40e-01	4.40e-04	1.60e-24	2.03e-19
Covid Exclusive	BRCA-rare-q001 Exclusive	2.95e-08	4.02e-01	6.23e-09	5.12e-15
BRCA-rare-q001 Exclusive	Covid Exclusive	8.56e-01	8.40e-04	3.60e-25	4.01e-18
Covid Exclusive	Overlap	1.69e-04	3.23e-04	1.69e-04	2.24e-04
BRCA-rare-q001 Exclusive	Overlap	5.87e-01	3.58e-01	1.95e-03	6.90e-03
Overlap	Exclusives	1.88e-17	1.67e-13	3.62e-36	1.98e-42



Evaluating how well Covid genes are linked to BRCA-rare-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-rare-q001	0.75	-3.51	2.03	2.11	9.36
BRCA-rare-q001 Exclusive	Covid	0.78	0.22	3.54	1.77	9.39
Covid Exclusive	BRCA-rare-q001 Exclusive	0.74	-3.52	1.32	1.55	8.80
BRCA-rare-q001 Exclusive	Covid Exclusive	0.78	0.12	3.89	2.48	9.32
Covid Exclusive	Overlap	0.99	1.94	4.29	2.42	3.92
BRCA-rare-q001 Exclusive	Overlap	0.89	-0.27	1.27	1.53	2.95
Overlap	Exclusives	0.82	2.59	8.82	2.67	15.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	BRCA-rare-q001	0.02	-1.76	3.41	4.00	14.11
BRCA-rare-q001 Exclusive	Covid	0.01	-0.71	0.79	1.67	13.32
Covid Exclusive	BRCA-rare-q001 Exclusive	0.01	-2.26	1.08	1.67	13.64
BRCA-rare-q001 Exclusive	Covid Exclusive	0.01	-0.76	1.42	2.76	5.53
Covid Exclusive	Overlap	0.03	21.70	47.98	62.73	51.83
BRCA-rare-q001 Exclusive	Overlap	0.00	-0.40	-0.15	1.16	1.08
Overlap	Exclusives	0.07	9.08	46.05	13.93	68.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	82	78	SRY;UNC93B;HLA-DRB4;MBL3P
BRCA-rare-q001 Exclusive	115	115	
Overlap	4	4