Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	BRCA-all-q01	1.22e-07	3.03e-03	8.53e-08	5.83e-29
BRCA-all-q01 Exclusive	Casanova	5.21e-05	4.40e-06	1.13e-11	8.59e-10
Casanova Exclusive	BRCA-all-q01 Exclusive	2.62e-07	3.00e-03	1.93e-07	4.05e-29
BRCA-all-q01 Exclusive	Casanova Exclusive	5.48e-05	3.86e-06	8.74e-11	4.51e-09
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
BRCA-all-q01 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.46e-04	1.06e-04	2.20e-55	1.62e-31



Evaluating how well Casanova genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-all-q01	0.74	1.80	2.42	2.61	13.98
BRCA-all-q01 Exclusive	Casanova	0.96	2.46	5.31	2.24	5.79
Casanova Exclusive	BRCA-all-q01 Exclusive	0.74	2.02	2.61	2.13	13.31
BRCA-all-q01 Exclusive	Casanova Exclusive	0.96	2.26	4.98	2.54	5.55
Casanova Exclusive	Overlap	1.00	2.30	1.05	2.17	1.88
BRCA-all-q01 Exclusive	Overlap	0.99	0.89	0.85	1.27	1.85
Overlap	Exclusives	0.75	0.85	4.03	1.95	13.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-all-q01	0.03	4.92	5.30	8.35	25.21
BRCA-all-q01 Exclusive	Casanova	0.01	3.58	20.96	10.12	5.44
Casanova Exclusive	BRCA-all-q01 Exclusive	0.03	4.51	5.47	6.60	24.35
BRCA-all-q01 Exclusive	Casanova Exclusive	0.01	3.40	28.17	11.04	14.05
Casanova Exclusive	Overlap	0.01	40.46	20.86	35.83	28.81
BRCA-all-q01 Exclusive	Overlap	0.00	1.06	4.67	8.00	33.04
Overlap	Exclusives	0.04	2.50	11.46	3.74	33.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
BRCA-all-q01 Exclusive	244	241	DKK 1.00;SOS 1;2021-03-07 00:00:00
Overlap	1	1