Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	BRCA-all-q001	3.77e-04	2.18e-02	2.56e-05	7.50e-18
BRCA-all-q001 Exclusive	Casanova	2.19e-02	2.37e-04	2.49e-10	6.07e-08
Casanova Exclusive	BRCA-all-q001 Exclusive	2.67e-04	2.80e-02	5.00e-05	1.58e-18
BRCA-all-q001 Exclusive	Casanova Exclusive	1.79e-02	2.14e-04	1.72e-09	2.24e-07
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
BRCA-all-q001 Exclusive	Overlap	1.12e-01	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.06e-04	7.91e-05	5.00e-34	1.54e-21



Evaluating how well Casanova genes are linked to BRCA-all-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-all-q001	0.74	1.67	1.69	2.00	10.48
BRCA-all-q001 Exclusive	Casanova	0.94	1.48	5.28	2.35	5.57
Casanova Exclusive	BRCA-all-q001 Exclusive	0.73	1.92	1.88	2.17	10.10
BRCA-all-q001 Exclusive	Casanova Exclusive	0.94	1.55	4.87	2.07	4.89
Casanova Exclusive	Overlap	1.00	2.13	1.09	2.09	1.66
BRCA-all-q001 Exclusive	Overlap	0.99	0.63	0.96	1.40	1.86
Overlap	Exclusives	0.75	0.93	3.69	1.96	12.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-all-q001	0.02	4.30	4.18	6.35	14.03
BRCA-all-q001 Exclusive	Casanova	0.01	0.97	17.01	5.08	14.66
Casanova Exclusive	BRCA-all-q001 Exclusive	0.02	4.26	3.16	6.45	11.97
BRCA-all-q001 Exclusive	Casanova Exclusive	0.01	0.72	13.62	4.86	13.22
Casanova Exclusive	Overlap	0.01	41.07	20.29	41.05	8.69
BRCA-all-q001 Exclusive	Overlap	0.00	-0.00	6.01	6.57	11.40
Overlap	Exclusives	0.03	3.88	14.98	5.39	27.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
BRCA-all-q001 Exclusive	152	151	2021-03-07 00:00:00
Overlap	1	1