Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	BRCA-rare-q001	9.64e-04	4.43e-02	1.12e-04	1.27e-19
BRCA-rare-q001 Exclusive	Casanova	2.12e-01	5.36e-05	7.34e-10	6.51e-08
Casanova Exclusive	BRCA-rare-q001 Exclusive	8.33e-04	4.83e-02	3.00e-05	2.60e-19
BRCA-rare-q001 Exclusive	Casanova Exclusive	1.29e-01	3.76e-05	6.95e-09	5.57e-07
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.12e-01
BRCA-rare-q001 Exclusive	Overlap	1.57e-01	4.53e-01	9.92e-02	1.18e-01
Overlap	Exclusives	1.34e-03	4.65e-04	9.12e-33	3.52e-26



Evaluating how well Casanova genes are linked to BRCA-rare-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-rare-q001	0.77	2.49	1.59	2.00	8.44
BRCA-rare-q001 Exclusive	Casanova	0.93	1.11	4.34	2.15	5.26
Casanova Exclusive	BRCA-rare-q001 Exclusive	0.77	2.07	1.61	2.36	10.35
BRCA-rare-q001 Exclusive	Casanova Exclusive	0.93	1.20	4.40	1.99	4.36
Casanova Exclusive	Overlap	1.00	1.92	1.11	2.57	1.59
BRCA-rare-q001 Exclusive	Overlap	0.98	0.19	0.61	1.34	1.53
Overlap	Exclusives	0.80	1.08	4.70	1.91	12.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	BRCA-rare-q001	0.02	4.04	2.39	5.21	9.81
BRCA-rare-q001 Exclusive	Casanova	0.01	0.25	6.47	6.55	2.23
Casanova Exclusive	BRCA-rare-q001 Exclusive	0.02	3.17	2.10	5.89	9.49
BRCA-rare-q001 Exclusive	Casanova Exclusive	0.00	0.42	10.07	2.47	3.73
Casanova Exclusive	Overlap	0.01	15.42	21.08	71.13	2.65
BRCA-rare-q001 Exclusive	Overlap	0.00	-0.31	-0.43	3.24	4.54
Overlap	Exclusives	0.03	2.21	14.71	4.03	20.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
BRCA-rare-q001 Exclusive	118	118	
Overlap	1	1