Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q01	1.08e-07	1.82e-09	2.34e-71	6.23e-52
BRCA-all-q01 Exclusive	WaveAF1	8.33e-06	3.47e-05	1.13e-50	5.96e-41
WaveAF1 Exclusive	BRCA-all-q01 Exclusive	3.42e-06	2.27e-07	3.89e-51	8.28e-35
BRCA-all-q01 Exclusive	WaveAF1 Exclusive	1.04e-03	2.33e-03	8.35e-33	6.77e-29
WaveAF1 Exclusive	Overlap	4.05e-03	8.79e-04	9.14e-23	6.01e-20
BRCA-all-q01 Exclusive	Overlap	3.08e-03	1.14e-02	1.27e-19	2.16e-17
Overlap	Exclusives	4.31e-15	2.26e-11	1.32e-83	3.81e-61



Evaluating how well WaveAF1 genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q01	0.81	2.55	6.83	6.30	16.95
BRCA-all-q01 Exclusive	WaveAF1	0.84	4.73	6.62	5.89	14.13
WaveAF1 Exclusive	BRCA-all-q01 Exclusive	0.80	2.25	4.89	6.30	15.47
BRCA-all-q01 Exclusive	WaveAF1 Exclusive	0.83	3.09	5.12	5.55	11.91
WaveAF1 Exclusive	Overlap	0.84	3.52	4.91	4.68	10.53
BRCA-all-q01 Exclusive	Overlap	0.85	4.00	5.14	5.68	8.59
Overlap	Exclusives	0.81	4.31	8.79	7.01	22.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q01	0.07	5.00	14.05	21.62	82.16
BRCA-all-q01 Exclusive	WaveAF1	0.06	4.60	8.41	12.49	39.46
WaveAF1 Exclusive	BRCA-all-q01 Exclusive	0.05	5.48	9.46	19.98	44.41
BRCA-all-q01 Exclusive	WaveAF1 Exclusive	0.03	4.45	4.50	10.47	37.95
WaveAF1 Exclusive	Overlap	0.04	4.08	8.06	12.36	54.87
BRCA-all-q01 Exclusive	Overlap	0.03	4.23	9.04	7.63	51.33
Overlap	Exclusives	0.07	7.09	14.50	20.08	64.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF1 Exclusive	110	110	
BRCA-all-q01 Exclusive	190	187	SOS 1;2021-03-07 00:00:00;DKK 1.00
Overlap	55	55