Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q001	5.43e-06	7.29e-06	8.14e-50	5.00e-36
BRCA-all-q001 Exclusive	WaveAF1	6.02e-05	9.27e-04	4.42e-41	1.57e-36
WaveAF1 Exclusive	BRCA-all-q001 Exclusive	3.41e-04	3.47e-04	7.79e-36	1.04e-24
BRCA-all-q001 Exclusive	WaveAF1 Exclusive	1.22e-02	1.12e-02	1.27e-30	1.22e-26
WaveAF1 Exclusive	Overlap	7.04e-03	3.08e-03	4.08e-18	3.78e-15
BRCA-all-q001 Exclusive	Overlap	9.87e-04	5.70e-03	8.86e-15	1.02e-13
Overlap	Exclusives	5.28e-10	3.84e-09	8.52e-64	3.24e-49



Evaluating how well WaveAF1 genes are linked to BRCA-all-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q001	0.81	2.33	5.59	4.62	13.24
BRCA-all-q001 Exclusive	WaveAF1	0.83	2.93	5.98	5.80	12.83
WaveAF1 Exclusive	BRCA-all-q001 Exclusive	0.80	1.84	3.92	4.90	11.73
BRCA-all-q001 Exclusive	WaveAF1 Exclusive	0.81	1.90	4.36	5.77	13.27
WaveAF1 Exclusive	Overlap	0.85	3.26	4.20	4.28	8.29
BRCA-all-q001 Exclusive	Overlap	0.86	3.97	4.81	4.77	7.75
Overlap	Exclusives	0.81	4.23	8.09	7.53	17.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF1 Exclusive	BRCA-all-q001	0.05	4.60	8.45	15.71	34.42
BRCA-all-q001 Exclusive	WaveAF1	0.05	1.83	8.18	12.91	49.39
WaveAF1 Exclusive	BRCA-all-q001 Exclusive	0.03	5.16	6.48	13.78	40.88
BRCA-all-q001 Exclusive	WaveAF1 Exclusive	0.03	1.48	3.98	10.34	30.45
WaveAF1 Exclusive	Overlap	0.03	3.44	3.78	7.03	28.36
BRCA-all-q001 Exclusive	Overlap	0.02	1.86	11.34	11.13	61.12
Overlap	Exclusives	0.05	6.15	10.91	20.46	55.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF1 Exclusive	126	126	
BRCA-all-q001 Exclusive	114	113	2021-03-07 00:00:00
Overlap	39	39