Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q01	2.05e-07	6.55e-08	1.76e-68	1.88e-49
BRCA-all-q01 Exclusive	WaveAF01	4.73e-06	1.38e-04	1.89e-44	2.46e-42
WaveAF01 Exclusive	BRCA-all-q01 Exclusive	1.76e-04	8.69e-05	1.16e-52	5.48e-34
BRCA-all-q01 Exclusive	WaveAF01 Exclusive	2.44e-03	3.32e-03	2.60e-26	2.72e-25
WaveAF01 Exclusive	Overlap	6.12e-05	6.01e-07	2.35e-25	1.86e-21
BRCA-all-q01 Exclusive	Overlap	4.41e-04	1.45e-03	6.27e-21	9.37e-21
Overlap	Exclusives	1.86e-09	1.28e-08	7.13e-88	1.66e-56



Evaluating how well WaveAF01 genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q01	0.80	3.68	6.80	5.54	16.04
BRCA-all-q01 Exclusive	WaveAF01	0.85	2.74	5.92	6.49	15.36
WaveAF01 Exclusive	BRCA-all-q01 Exclusive	0.77	2.77	4.27	4.86	13.52
BRCA-all-q01 Exclusive	WaveAF01 Exclusive	0.82	2.31	4.22	4.92	11.24
WaveAF01 Exclusive	Overlap	0.92	4.29	5.31	5.65	11.31
BRCA-all-q01 Exclusive	Overlap	0.91	2.66	4.57	4.14	10.44
Overlap	Exclusives	0.79	3.14	6.82	6.65	16.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q01	0.07	6.09	15.30	19.19	62.85
BRCA-all-q01 Exclusive	WaveAF01	0.05	1.78	6.46	13.99	40.79
WaveAF01 Exclusive	BRCA-all-q01 Exclusive	0.04	5.08	9.76	13.21	40.55
BRCA-all-q01 Exclusive	WaveAF01 Exclusive	0.02	1.46	4.48	8.38	33.94
WaveAF01 Exclusive	Overlap	0.04	4.13	8.26	30.67	51.68
BRCA-all-q01 Exclusive	Overlap	0.03	1.58	4.76	10.87	43.19
Overlap	Exclusives	0.06	3.91	11.26	19.90	39.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF01 Exclusive	95	95	
BRCA-all-q01 Exclusive	198	195	2021-03-07 00:00:00;SOS 1;DKK 1.00
Overlap	47	47